mephenytoin indications/contra

Stem definitionDrug idCAS RN
antiepileptics, hydantoin derivatives 1695 50-12-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mephenytoin
  • DL-Mephenytoin
  • epiazin
  • fenantoin
  • mesantoin
  • mesdontoin
  • mesontoin
  • methoin
  • methylphenetoin
  • phenantoin
  • phenylethylmethylhydantoin
An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
  • Molecular weight: 218.26
  • Formula: C12H14N2O2
  • CLOGP: 2
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.41
  • ALOGS: -2.35
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.40 g O

Approvals:

DateAgencyCompanyOrphan
Oct. 23, 1946 FDA NOVARTIS

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N03AB04 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Hydantoin derivatives
ATC N03AB54 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Hydantoin derivatives
FDA EPC N0000175753 Anti-epileptic Agent
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Epilepsy indication 84757009 DOID:1826
Localization-related epilepsy indication 230381009 DOID:2234
Motor cortex epilepsy indication 267592003
Epilepsy characterized by intractable complex partial seizures indication 442481002

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel alpha subunit Ion channel BLOCKER CHEMBL CHEMBL

External reference:

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IDSource
DB00532 DRUGBANK_ID
4018756 VUID
N0000147059 NUI
C0025381 UMLSCUI
7223 IUPHAR_LIGAND_ID
D00375 KEGG_DRUG
CHEMBL861 ChEMBL_ID
4060 PUBCHEM_CID
4018756 VANDF
6757 RXNORM
28344001 SNOMEDCT_US
5048 MMSL
d00941 MMSL
417526007 SNOMEDCT_US
N0000006396 NDFRT
N0000147059 NDFRT
001621 NDDF
CHEBI:6757 CHEBI
D008617 MESH_DESCRIPTOR_UI
R420KW629U UNII
1463 INN_ID

Pharmaceutical products:

None