motretinide indications/contra

Stem definitionDrug idCAS RN
retinol derivatives 1849 56281-36-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • motretinide
  • tasmadem
  • tasmaderm
  • molrelinid
exerts a therapeutic influence on chemically induced papillomas & carcinomas of the skin in mice; RN given refers to cpd without isomeric designation; structure
  • Molecular weight: 353.51
  • Formula: C23H31NO2
  • CLOGP: 6.16
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 1
  • TPSA: 38.33
  • ALOGS: -5.66
  • ROTB: 7

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC D10AD05 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Retinoids for topical use in acne

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Acne vulgaris indication 88616000

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.23 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
D05082 KEGG_DRUG
CHEMBL519260 ChEMBL_ID
6314185 PUBCHEM_CID
W786807KL1 UNII
4233 INN_ID
C010832 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135490 CHEBI

Pharmaceutical products:

None